*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SZ1300000
CHEMICAL NAME : Phosphine oxide,
1,4-piperazinediylbis(bis(1-aziridinyl)-
CAS REGISTRY NUMBER : 738-99-8
BEILSTEIN REFERENCE NO. : 0629375
REFERENCE : 5-23-03-00231 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C12-H24-N6-O2-P2
MOLECULAR WEIGHT : 346.36
WISWESSER LINE NOTATION : T6N DNTJ APO&- AT3NTJ&- AT3NTJ& DPO&- AT3NTJ&- AT3NTJ
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* 1,4-Bis(N,N'-diethylene phosphamide)piperazine
* Dipin
* Dipine
* ENT-50107
* Piperazine, 1,4-bis(bis(1-aziridinyl)phosphinyl)-
* 1,4-Piperazinediylbis(bis(1-aziridinyl)phosphine oxide)
* Tetra-ethyleneimidepiperazine-N,N'-diphosphoric acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 68 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
UK) V.30- 1967- Volume(issue)/page/year: 36,240,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 90 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 14,363,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 58 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 21,262,1976
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 24 mmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 11,648,1969
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 1 pph/3H (Continuous)
REFERENCE :
AESAAI Annals of the Entomological Society of America. (Entomological Soc.
of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
Volume(issue)/page/year: 62,790,1969
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 24 mmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 11,648,1969
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 29 umol/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
10,1580,1974
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 mg/L
REFERENCE :
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English
translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1- 1967- Volume(issue)/page/year: 16(2),34,1982
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 60 mg/kg
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
11,1347,1975
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 60 mg/kg
REFERENCE :
IANBAM Izvestiya Akademii Nauk SSSR, Seriya Biologicheskaya. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936-
Volume(issue)/page/year: (6),816,1991
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 10 mg/kg
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
Volume(issue)/page/year: 19(1),23,1985
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 2 mg/kg
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
Volume(issue)/page/year: 19(1),23,1985
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION : 5700 nmol/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
18,210,1982
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Mammal - pig
DOSE/DURATION : 20 mg/kg
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
Volume(issue)/page/year: 10(6),54,1976
*** END OF RECORD ***