*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SZ6563500
CHEMICAL NAME           : Phosphonic acid,
                          ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)-
CAS REGISTRY NUMBER     : 106941-25-7
BEILSTEIN REFERENCE NO. : 3561094
LAST UPDATED            : 199712
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C8-H12-N5-O4-P
MOLECULAR WEIGHT        : 273.22
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
   * 9-(2-Phosphonylmethoxyethyl)adenine
   * PMEA
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 40,1072,1996
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 40,1072,1996
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 100 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 311,305,1994
 
                            *** END OF RECORD ***