*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SY8200000
CHEMICAL NAME           : Phosphinecarboxylic acid, dihydroxy-, oxide,
                          trisodium salt
CAS REGISTRY NUMBER     : 63585-09-1
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C-O5-P.3Na
MOLECULAR WEIGHT        : 191.95
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * A 29622
   * Dihydroxyphosphinecarboxylic acid oxide trisodium salt
   * Foscarnet sodium
   * Phosphonoformic acid, trisodium salt
   * Trisodium carboxyphosphate
   * Trisodium phosphonoformate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2400 mg/kg/6D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,216,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 384 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4215113
 
                            *** END OF RECORD ***