*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SO8925000
CHEMICAL NAME           : Phenothiazine,
                          10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 1098-60-8
LAST UPDATED            : 199012
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C18-H19-F3-N2-S.Cl-H
MOLECULAR WEIGHT        : 388.91
WISWESSER LINE NOTATION : T C666 BN ISJ B3N1&1 EXFFF
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 10-(3-Dimethylaminopropyl)-2-(trifluoromethyl)phenothiazine hydrochloride
   * Trifluopromazine hydrochloride
   * Triflupromazine hydrochloride
   * Vesprin hydrochloride
   * 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-,  
   monohydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 94 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
   Behavioral - ataxia
REFERENCE :
   MTHEA8 Monographs on Therapy.  (The Squibb Institute for Medical Research,
   New Brunswick, NJ)  Volume(issue)/page/year: 2,214,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 254 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,56,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 102 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
   Behavioral - ataxia
REFERENCE :
   MTHEA8 Monographs on Therapy.  (The Squibb Institute for Medical Research,
   New Brunswick, NJ)  Volume(issue)/page/year: 2,214,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 34 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,56,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory obstruction
   Blood - hemorrhage
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 127,55,1959
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mammal - species unspecified Kidney
DOSE/DURATION           : 20 mg/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 8,617,1970
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Mammal - species unspecified Kidney
DOSE/DURATION           : 10 mg/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 8,617,1970
 
                            *** END OF RECORD ***