*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SN7700000
CHEMICAL NAME           : 10H-Phenothiazine,
                          2-chloro-10-(3-(1,4-diazabicyclo(4.3.0)nonanyl)propio
                          nyl)-, dihydrochloride
CAS REGISTRY NUMBER     : 49780-10-1
LAST UPDATED            : 198610
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H24-Cl-N3-O-S.2Cl-H
MOLECULAR WEIGHT        : 486.92
WISWESSER LINE NOTATION : T C666 BN ISJ EG BV2- HT56 AN GMTJ &GH 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AY-25,329
   *   2-Chloro-10-(3-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-propionyl)pheno
     thiazine 2HCL
   *   10'-(beta-(1,4-Diazabicyclo(4.3.0)nonanyl-4)-propionyl)-2'-chlorophenthi
     azin dichloride
   * Nonachlazine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 42,243,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 44,342,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 38,732,1975
 
                            *** END OF RECORD ***