*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SN7600000
CHEMICAL NAME           : Phenothiazine,
                          2-chloro-10-(3-(N-cyclopentyl-N-methyl)aminopropyl)-
CAS REGISTRY NUMBER     : 63833-99-8
LAST UPDATED            : 199107
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C21-H25-Cl-N2-S.Cl-H
MOLECULAR WEIGHT        : 409.45
WISWESSER LINE NOTATION : T C666 BN ISJ EG B3N1&- AL5TJ
SYNONYMS/TRADE NAMES :
   * Ciba 17040
   * 10-(3-(N-Cyclopentyl-N-methyl)aminopropyl)-2-chlorophenothiazine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   ACAEAS Acta Anaesthesiologica.  (Padua, Italy)  V.1-22, 1950-71.  For
   publisher information, see AANIBO.  Volume(issue)/page/year: 9,377,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   ACAEAS Acta Anaesthesiologica.  (Padua, Italy)  V.1-22, 1950-71.  For
   publisher information, see AANIBO.  Volume(issue)/page/year: 9,377,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 54 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   ACAEAS Acta Anaesthesiologica.  (Padua, Italy)  V.1-22, 1950-71.  For
   publisher information, see AANIBO.  Volume(issue)/page/year: 9,377,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   ACAEAS Acta Anaesthesiologica.  (Padua, Italy)  V.1-22, 1950-71.  For
   publisher information, see AANIBO.  Volume(issue)/page/year: 9,377,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   ACAEAS Acta Anaesthesiologica.  (Padua, Italy)  V.1-22, 1950-71.  For
   publisher information, see AANIBO.  Volume(issue)/page/year: 9,377,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   ACAEAS Acta Anaesthesiologica.  (Padua, Italy)  V.1-22, 1950-71.  For
   publisher information, see AANIBO.  Volume(issue)/page/year: 9,377,1958
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   ACAEAS Acta Anaesthesiologica.  (Padua, Italy)  V.1-22, 1950-71.  For
   publisher information, see AANIBO.  Volume(issue)/page/year: 9,377,1958
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   ACAEAS Acta Anaesthesiologica.  (Padua, Italy)  V.1-22, 1950-71.  For
   publisher information, see AANIBO.  Volume(issue)/page/year: 9,377,1958
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   ACAEAS Acta Anaesthesiologica.  (Padua, Italy)  V.1-22, 1950-71.  For
   publisher information, see AANIBO.  Volume(issue)/page/year: 9,377,1958
 
                            *** END OF RECORD ***