*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SN7350000
CHEMICAL NAME           : Phenothiazine-10-carboxylic acid,
                          2-(diethylamino)ethyl ester, hydrochloride
CAS REGISTRY NUMBER     : 298-51-1
LAST UPDATED            : 199803
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H22-N2-O2-S.Cl-H
MOLECULAR WEIGHT        : 378.95
WISWESSER LINE NOTATION : T C666 BN ISJ BVO2N2&2 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * beta-Diethylaminoethyl phenothiazine-N-carboxylate hydrochloride
   * beta-Diethylaminoethyl phenothiazine-10-carboxylate hydrochloride
   * Novazin
   * Novazin hydrochloride
   * 10-Phenothiazinecarboxylic acid beta-diethylaminoethyl ester  
   hydrochloride
   * Phenothiazine-10-carboxylic acid, 2-(diethylamino)ethyl ester,  
   monohydrochloride
   * Transergan
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   13,59,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   13,59,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   13,59,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 90,241,1952
 
                            *** END OF RECORD ***