*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SM8750000
CHEMICAL NAME           : Phenol, 4,4'-(2-pyridylmethylene)di-, diacetate
                          (ester)
CAS REGISTRY NUMBER     : 603-50-9
BEILSTEIN REFERENCE NO. : 0323727
REFERENCE               : 5-21-05-00415 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C22-H19-N-O4
MOLECULAR WEIGHT        : 361.42
WISWESSER LINE NOTATION : T6NJ BYR DOV1&R DOV1
SYNONYMS/TRADE NAMES :
   * Bicol
   * Bis(p-acetoxyphenyl)-2-pyridylmethane
   * Bisacodyl
   * Broxalax
   * Deficol
   * 2-(4,4'-Diacetoxydiphenylmethyl)pyridine
   * (4,4'-Diacetoxydiphenyl)(2-pyridyl)methane
   * 4,4'-Diacetoxydiphenylpyrid-2-ylmethane
   * Di-(p-acetoxyphenyl)-2-pyridylmethane
   * Di-(4-acetoxyphenyl)-2-pyridylmethane
   * Dulcolan
   * Dulcolax
   * Durolax
   * Endokolat
   * Eulaxan
   * Godalax
   * Hillcolax
   * Ivilax
   * LA96a
   * LACO
   * Laxadin
   * Laxanin N
   * Laxans
   * Laxorex
   * Neolax
   * Nigalax
   * Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)
   * 4,4'-(2-Pyridylmethylene)diphenol diacetate
   * Pyrilax
   * Sanvacual
   * SK-Bisacodyl
   * Stadalax
   * Telemin
   * Theralax
   * Ulcolax
   * Zetrax
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4320 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Gastrointestinal - other changes
   Blood - changes in spleen
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,243,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17500 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory stimulation
   Blood - hemorrhage
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,243,1960
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,243,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >15 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,854,1990
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 3,19,1953
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 3,19,1953
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 3,19,1953

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   DAPOAG Deutsche Apotheker.  (Postfach 1650, 6370 Oberusel/Taunas, Fed. Rep.
   Ger.)  V.1-    1949-  Volume(issue)/page/year: 27,151,1975

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - A1651
       No. of Facilities: 86 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 431 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - A1651
       No. of Facilities: 132 (estimated)
       No. of Industries: 2
       No. of Occupations: 8
       No. of Employees: 2964 (estimated)
       No. of Female Employees: 1874 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***