*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SM8380000
CHEMICAL NAME : Phenolphthalein
CAS REGISTRY NUMBER : 77-09-8
OTHER CAS REGISTRY NOS. : 467-29-8
57214-20-7
BEILSTEIN REFERENCE NO. : 0284423
REFERENCE : 5-18-04-00188 (Beilstein Handbook Reference)
LAST UPDATED : 199803
DATA ITEMS CITED : 20
MOLECULAR FORMULA : C20-H14-O4
MOLECULAR WEIGHT : 318.34
WISWESSER LINE NOTATION : T56 BVO DHJ D- D-/R DQ 2
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Agoral
* Alophen
* 3,3-Bis(p-hydroxyphenyl)phthalide
* Colax
* Correctol
* Dialose
* alpha-Di(p-hydroxyphenyl)phthalide
* Dihydroxyphthalophenone
* Doxidan
* Euchessina
* Evac-Q-Kit
* Evac-Q-Kwik
* Evac-U-Gen
* Evac-V-Lax
* Ex-Lax
* Feen-a-mint gum
* FemiLax
* Fenolftalein
* alpha-(p-Hydroxyphenyl)-alpha-(4-oxo-2,5-cyclohexadien-1-ylidene)-o-tolu
ic acid
* 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-
* Kondremul
* Koprol
* Laxogen
* LaxCaps
* Lax-Pills
* Lilo
* Medilax
* Modane
* NCI-C55798
* Phenolax
* Phthalide 3,3,-bis(p-hydroxyphenyl)-
* Phthalimetten
* Phthalin
* Prulet
* Purga
* Purgen
* Purgophen
* Spulmako-lax
* Trilax
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 29 mg/kg
TOXIC EFFECTS :
Gastrointestinal - gastritis
Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB
88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 60,491,1984
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,25,1953
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,30,1953
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 324 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
18,48,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 106 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in erythrocyte (RBC) count
Related to Chronic Data - changes in testicular weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
18,48,1992
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 364 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
Endocrine - adrenal cortex tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-465,1996
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 281 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - tumors
Skin and Appendages - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-465,1996
** MUTATION DATA **
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 1680 mg/kg/14D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 341,151,1995
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 341,151,1995
*** REVIEWS ***
TOXICOLOGY REVIEW
DAPOAG Deutsche Apotheker. (Postfach 1650, 6370 Oberusel/Taunas, Fed. Rep.
Ger.) V.1- 1949- Volume(issue)/page/year: 27,151,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0011
No. of Facilities: 8 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 31 (estimated)
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 56240
No. of Facilities: 6160 (estimated)
No. of Industries: 102
No. of Occupations: 43
No. of Employees: 43092 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9187
No. of Facilities: 117 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 1946 (estimated)
No. of Female Employees: 1408 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 56240
No. of Facilities: 6900 (estimated)
No. of Industries: 89
No. of Occupations: 57
No. of Employees: 73297 (estimated)
No. of Female Employees: 18309 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis Studies (feed);clear evidence:mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-465,1996
NTP Carcinogenesis Studies (feed);some evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-465,1996
*** END OF RECORD ***