*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BQ5870000
CHEMICAL NAME           : Ammonium, ethyl(m-hydroxyphenyl)dimethyl-, chloride
CAS REGISTRY NUMBER     : 116-38-1
LAST UPDATED            : 199504
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H16-N-O.Cl
MOLECULAR WEIGHT        : 201.72
WISWESSER LINE NOTATION : QR CK2&1&1 &G
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Ammonium, dimethylethyl(m-hydroxyphenyl)-, chloride
   * Antirex
   * Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride
   * Edrophonium chloride
   * Ethyl(m-hydroxyphenyl)dimethylammonium chloride
   * Tensilon
   * Tensilon chloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 10,327,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 52 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - muscle weakness
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 123,121,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 115,185,1955

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5548
       No. of Facilities: 17 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 8250 (estimated)
       No. of Female Employees: 7491 (estimated)

 
                            *** END OF RECORD ***