*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SL7875000
CHEMICAL NAME           : Phenol, 2-methoxy-4-propenyl-
CAS REGISTRY NUMBER     : 97-54-1
BEILSTEIN REFERENCE NO. : 1909602
REFERENCE               : 3-06-00-04993 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C10-H12-O2
MOLECULAR WEIGHT        : 164.22
WISWESSER LINE NOTATION : 2U1R DQ CO1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * 1-Hydroxy-2-methoxy-4-propenylbenzene
   * 4-Hydroxy-3-methoxy-1-propenylbenzene
   * Isoeugenol
   * 2-Methoxy-4-propenylphenol
   * NCI-C60979
   * 4-Propenylguaiacol
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 16 mg/48H
REACTION SEVERITY       : Moderate
REFERENCE :
   CTOIDG Cosmetics and Toiletries.  (Allured Pub. Corp., POB 318, Wheaton, IL
   60189)  V.91-    1976-  Volume(issue)/page/year: 94(8),41,1979
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/24H
REACTION SEVERITY       : Severe
REFERENCE :
   CTOIDG Cosmetics and Toiletries.  (Allured Pub. Corp., POB 318, Wheaton, IL
   60189)  V.91-    1976-  Volume(issue)/page/year: 94(8),41,1979
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 100 mg/24H
REACTION SEVERITY       : Severe
REFERENCE :
   CTOIDG Cosmetics and Toiletries.  (Allured Pub. Corp., POB 318, Wheaton, IL
   60189)  V.91-    1976-  Volume(issue)/page/year: 94(8),41,1979
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1560 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   6,378,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 328 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 104,793,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1410 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - coma
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 2,327,1964
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 250 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 169,129,1986

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83233
       No. of Facilities: 94 (estimated)
       No. of Industries: 5
       No. of Occupations: 25
       No. of Employees: 5786 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83233
       No. of Facilities: 3651 (estimated)
       No. of Industries: 10
       No. of Occupations: 19
       No. of Employees: 35171 (estimated)
       No. of Female Employees: 24980 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NTP Carcinogenesis studies; selected, October 1997

 
                            *** END OF RECORD ***