*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SL0580000
CHEMICAL NAME           : Phenol, 4,4'-(diethylideneethylene)di-
CAS REGISTRY NUMBER     : 84-17-3
LAST UPDATED            : 199512
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C18-H18-O2
MOLECULAR WEIGHT        : 266.36
WISWESSER LINE NOTATION : QR DYU2&YU2&R DQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Agaldog
   * 3,4-Bis(p-hydroxyphenyl)-2,4-hexadiene
   * 3,4-Bis(4-hydroxyphenyl)-2,4-hexadiene
   * Cycladiene
   * Dehydrostilbestrol
   * Dehydrostilboestrol
   * Dienestrol
   * Dienoestrol
   * beta-Dienoestrol
   * Dienol
   * 4,4'-(1,2-Diethylidene-1,2-ethanediyl)bisphenol
   * p,p'-(Diethylideneethylene)diphenol
   * 4,4'-(Diethylideneethylene)diphenol
   * Dinovex
   * Di(p-oxyphenyl)-2,4-hexadiene
   * DV
   * Estragard
   * Estrodienol
   * Estroral
   * Follidiene
   * Follormon
   * Gynefollin
   * Mesohexestrol
   * Hormofemin
   * 4,4'-Hydroxy-gamma,delta-diphenyl-beta,delta-hexadiene
   * Oestrasid
   * Oestrodiene
   * Oestroral
   * Oestrovis
   * Para-dien
   * Phenol, 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis-
   * Restrol
   * Retalon
   * Sexadien
   * Teserene
   * Willnestrol
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 ug/kg
SEX/DURATION            : female 3 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 13,101,1967
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 5 nmol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 281,392,1979
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,14,1988
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 3 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,184,1984
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 75 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 171,31,1986

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Limited Evidence
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,278,1987

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83633
       No. of Facilities: 124 (estimated)
       No. of Industries: 2
       No. of Occupations: 7
       No. of Employees: 2882 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83633
       No. of Facilities: 9 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 166 (estimated)
       No. of Female Employees: 105 (estimated)

 
                            *** END OF RECORD ***