*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SJ7800000
CHEMICAL NAME           : Phenol,
                          2,6-bis(piperidinomethyl)-4-(alpha,alpha-dimethylbenz
                          yl)-, dihydrobromide
CAS REGISTRY NUMBER     : 2089-46-5
LAST UPDATED            : 199009
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C27-H38-N2-O.2Br-H
MOLECULAR WEIGHT        : 568.51
WISWESSER LINE NOTATION : T6NTJ A1R BQ EX1&1&R& C1- AT6NTJ &EH 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-(Bis(2-chloroethyl)amino)phenol
   * 2,6-Bis(1-piperidylmethyl)-4-(alpha,alpha-dimethylbenzyl)phenol  
   dihydrobromide
   * 4-alpha,alpha-Dimethylbenzyl-alpha,alpha'-dipiperidino-2,6-xylenol  
   dihydrobromide
   * 4-(1-Methyl-1-phenylethyl)-2,6-bis-(1-piperidinylmethyl)phenol  
   dihydrobromide
   * Ro 2-5803
   * Rythmol
   * 2,6-Xylenol, 4-alpha,alpha-dimethylbenzyl-alpha,alpha'-dipiperidino-,  
   dihydrobromide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 8,167,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 132,295,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 8,167,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 132,295,1961
 
                            *** END OF RECORD ***