*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SG1400000
CHEMICAL NAME : Phenazine, 3-amino-7-(dimethylamino)-2-methyl-,
hydrochloride
CAS REGISTRY NUMBER : 553-24-2
LAST UPDATED : 199701
DATA ITEMS CITED : 22
MOLECULAR FORMULA : C15-H16-N4.Cl-H
MOLECULAR WEIGHT : 288.81
WISWESSER LINE NOTATION : T C666 BN INJ E1 FZ LN1&1 &GH
COMPOUND DESCRIPTOR : Drug
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* 3-Amino-7-dimethylamino-2-methylphenazine hydrochloride
* Aminodimethylaminotoluaminozine hydrochloride
* Cerven neutralni
* Cerven toluylenova
* Cerven zasadita 5
* C.I. 50040
* C.I. Basic Red 5
* C.I. Basic Red 5, monohydrochloride
* Kernechtrot
* Michrome No. 226
* Neutral Red
* Neutral Red chloride
* Neutral Red W
* Nuclear Fast Red
* Phenazine, 3-amino-7-(dimethylamino)-2-methyl-, monohydrochloride
* Toluylene Red
* N(sup 8),N(sup 8),3-Trimethyl-2,8-phenazinediamine monohydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 112 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 10,337,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 432 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
1989- Volume(issue)/page/year: 25,356,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 142 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 10,337,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 96600 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62.
Discontinued. Volume(issue)/page/year: 9,96,1951
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 25 ug/plate
REFERENCE :
AEMIDF Applied and Environmental Microbiology. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976-
Volume(issue)/page/year: 42,641,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2500 ppt/3H
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB
37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year:
85,119,1951
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2 ug/well
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,429,1981
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 144 mg/L
REFERENCE :
FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29
Prague 1, Czechoslavakia) V.4- 1959- Volume(issue)/page/year:
22,329,1977
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 1000 ppm
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB
37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year:
87,295,1953
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Fish - not otherwise specified
DOSE/DURATION : 1 ppm/4D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 64,205,1979
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 93,185,1982
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 96 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
22,287,1978
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 2 umol/L/5H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 45,233,1977
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 85 ug/kg
REFERENCE :
47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed.,
Totowa, NJ, Allanheld, Osmun & Co., 1982 Volume(issue)/page/year:
-,137,1982
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 85 ug/kg
REFERENCE :
47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed.,
Totowa, NJ, Allanheld, Osmun & Co., 1982 Volume(issue)/page/year:
-,137,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1598
No. of Facilities: 420 (estimated)
No. of Industries: 5
No. of Occupations: 5
No. of Employees: 694 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1598
No. of Facilities: 746 (estimated)
No. of Industries: 13
No. of Occupations: 12
No. of Employees: 23740 (estimated)
No. of Female Employees: 19202 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***