*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SH6820000
CHEMICAL NAME           : Phenethylamine,
                          N-ethyl-alpha-methyl-m-(trifluoromethyl)-
CAS REGISTRY NUMBER     : 458-24-2
BEILSTEIN REFERENCE NO. : 4783711
LAST UPDATED            : 199709
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C12-H16-F3-N
MOLECULAR WEIGHT        : 231.29
WISWESSER LINE NOTATION : FXFFR C1YM2
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-
   * N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine
   * Fenfluramine
   * 3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
   * 1-(meta-Trifluoromethyl-phenyl)-2 ethylaminopropane
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle contraction or spasticity
   Cardiac - other changes
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,1306,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 4286 ug/kg
TOXIC EFFECTS :
   Autonomic Nervous System - sympathomimetic
   Behavioral - hallucinations, distorted perceptions
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 34,205,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,177,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 188,271,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 53 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - rigidity (including catalepsy)
   Skin and Appendages - hair
REFERENCE :
   17XKAB "International Symposium on Amphetamines and Related Compounds,
   Proceedings, Mario Negri Institute for Pharmacological Research, Milan,
   1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970
   Volume(issue)/page/year: -,75,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - rigidity (including catalepsy)
   Skin and Appendages - hair
REFERENCE :
   17XKAB "International Symposium on Amphetamines and Related Compounds,
   Proceedings, Mario Negri Institute for Pharmacological Research, Milan,
   1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970
   Volume(issue)/page/year: -,75,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - rigidity (including catalepsy)
   Skin and Appendages - hair
REFERENCE :
   17XKAB "International Symposium on Amphetamines and Related Compounds,
   Proceedings, Mario Negri Institute for Pharmacological Research, Milan,
   1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970
   Volume(issue)/page/year: -,75,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - rigidity (including catalepsy)
   Skin and Appendages - hair
REFERENCE :
   17XKAB "International Symposium on Amphetamines and Related Compounds,
   Proceedings, Mario Negri Institute for Pharmacological Research, Milan,
   1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970
   Volume(issue)/page/year: -,75,1970
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 280 mg/kg
SEX/DURATION            : female 7-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 17,39A,1978

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   PHJOAV Pharmaceutical Journal.  (Pharmaceutical Soc. of Great Britain, 1
   Lambeth High St., London, SE1 7JN, UK)  V.131-    1933-
   Volume(issue)/page/year: 213,159,1974

 
                            *** END OF RECORD ***