*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SG1623000
CHEMICAL NAME           : Phenazinium, 3,7-diamino-2,8-dimethyl-5-phenyl-,
                          chloride
CAS REGISTRY NUMBER     : 477-73-6
LAST UPDATED            : 199701
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C20-H19-N4.Cl
MOLECULAR WEIGHT        : 350.88
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Basic Red 2
   * Brilliant safranine BR
   * Brilliant safranine G
   * Brilliant safranine GR
   * Calcozine Red Y
   * Cerven zasadita 2
   * C.I. 50240
   * C.I. Basic Red 2
   * 2,8-Dimethylphenosafranine
   * Gossypimine
   * Hidaco safranine
   * Leather Red HT
   * Mitsui safranine
   * Nippon kagaku safranine GK
   * Nippon kagaku safranine T
   * Safranin
   * Safranine
   * Safranine A
   * Safranine B
   * Safranine G
   * Safranine GF
   * Safranine J
   * Safranine O
   * Safranine OK
   * Safranine superfine G
   * Safranine T
   * Safranine TH
   * Safranine TN
   * Safranine Y
   * Safranine YN
   * Safranine ZH
   * Safranin T
   * Tolusafranine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28740 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   SMBUA9 Stanford Medical Bulletin.  (Palo Alto, CA)  V.1-20, 1942-62.
   Discontinued.  Volume(issue)/page/year: 9,96,1951
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 69,327,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 24020 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   SMBUA9 Stanford Medical Bulletin.  (Palo Alto, CA)  V.1-20, 1942-62.
   Discontinued.  Volume(issue)/page/year: 9,96,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 26940 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   SMBUA9 Stanford Medical Bulletin.  (Palo Alto, CA)  V.1-20, 1942-62.
   Discontinued.  Volume(issue)/page/year: 9,96,1951
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 16 ug/plate
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 27,153,1976
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 4 ug/well
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,429,1981
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 2 mg/disc
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 27,153,1976

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M1441
       No. of Facilities: 1027 (estimated)
       No. of Industries: 9
       No. of Occupations: 18
       No. of Employees: 4314 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M1441
       No. of Facilities: 1253 (estimated)
       No. of Industries: 6
       No. of Occupations: 10
       No. of Employees: 22263 (estimated)
       No. of Female Employees: 14330 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***