*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SF7950000
CHEMICAL NAME : Phenanthridinium, 3,8-diamino-5-ethyl-6-phenyl-,
bromide
CAS REGISTRY NUMBER : 1239-45-8
LAST UPDATED : 199712
DATA ITEMS CITED : 79
MOLECULAR FORMULA : C21-H20-N3.Br
MOLECULAR WEIGHT : 394.35
WISWESSER LINE NOTATION : T B666 HKJ EJ H2 IR& LZ &E &9/26
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* 2,7-Diamino-10-ethyl-9-phenylphenanthridinium bromide
* 3,8-Diamino-5-ethyl-6-phenylphenanthridinium bromide
* 2,7-Diamino-9-phenyl-10-ethylphenanthridinium bromide
* 2,7-Diamino-9-phenylphenanthridine ethobromide
* Dromilac
* Ethidium bromide
* Homidium bromide
* RD 1572
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
34,2699,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATMPA2 Annals of Tropical Medicine and Parasitology. (Grune & Stratton,
Inc., POB 6280, Duluth, MN 55806) V.1- 1907- Volume(issue)/page/year:
46,285,1952
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 200 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 127,31,1984
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,239,1987
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
Volume(issue)/page/year: 4,286,1974
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 mg/L
REFERENCE :
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher
information, see CRASEV. Volume(issue)/page/year: 269,1708,1969
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 250 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 41,61,1976
TYPE OF TEST : DNA adduct
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 15 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 500 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
20,2921,1971
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 ug/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,2819,1983
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 6 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 50 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 74,113,1980
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 10 gm/L
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year:
126,959,1976
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 5 umol/L
REFERENCE :
JDREAF Journal of Dental Research. (International Assoc. for Dental
Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
Volume(issue)/page/year: 55,266,1976
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 25 mg/L
REFERENCE :
CUMIDD Current Microbiology. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978-
Volume(issue)/page/year: 8,201,1983
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 100 ug/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 55,248,1969
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 2 mg/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 55,248,1969
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 600 mg/L
REFERENCE :
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,141,1968
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 300 mg/L
REFERENCE :
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 77,479,1973
TYPE OF TEST : DNA damage
TEST SYSTEM : Non-mammalian species
DOSE/DURATION : 1 mol
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
561,77,1979
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 2 mg/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
Volume(issue)/page/year: 150,301,1977
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 100 ug/L
REFERENCE :
NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246,
1971-73. For publisher information, see NATUAS. Volume(issue)/page/year:
232,143,1971
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 50 mg/L
REFERENCE :
IJBBBQ Indian Journal of Biochemistry and Biophysics. (Publications &
Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.8-
1971- Volume(issue)/page/year: 19,285,1982
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 2500 ug/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 26,75,1979
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 3 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,203,1982
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 3 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 138,169,1984
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,203,1982
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 5 umol/L
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,
1255 Howard St., San Francisco, CA 94103) V.6- 1958-
Volume(issue)/page/year: 34,1735,1986
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 1 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
Volume(issue)/page/year: 4,286,1974
TYPE OF TEST : DNA adduct
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 50 umol/L
REFERENCE :
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD
21202) V.1- 1905- Volume(issue)/page/year: 249,6617,1974
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Schizosaccharomyces pombe
DOSE/DURATION : 2 mg/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
Volume(issue)/page/year: 144,75,1976
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Protozoa - Euglena gracilis
DOSE/DURATION : 1 mg/L
REFERENCE :
JNCSAI Journal of Cell Science. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1966-
Volume(issue)/page/year: 13,567,1973
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Non-mammalian species
DOSE/DURATION : 63400 nmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,17,1989
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION : 50 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 222,193,1969
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION : 10 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 222,193,1969
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION : 10 mmol/L
REFERENCE :
AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.
(SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987. For publisher
information, see BSTME2. Volume(issue)/page/year: 62,365,1973
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION : 10 mmol/L
REFERENCE :
AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.
(SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987. For publisher
information, see BSTME2. Volume(issue)/page/year: 62,365,1973
TYPE OF TEST : DNA adduct
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 2 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
11,101,1975
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 5 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 263,679,1976
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 40 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 92,427,1982
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 40 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
77,25,1991
TYPE OF TEST : DNA adduct
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 200 umol/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 100,223,1976
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 2500 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 10,393,1989
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 500 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,145,1983
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 mg/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
Volume(issue)/page/year: 2,379,1986
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Ascites tumor
DOSE/DURATION : 117 umol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
374,96,1974
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Mammary gland
DOSE/DURATION : 100 nmol/L
REFERENCE :
JOBIAO Journal of Biochemistry (Tokyo). (Japanese Biochemical Soc., c/o
Japan Academic Soc. Center, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.1-
1922- Volume(issue)/page/year: 84,145,1978
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,305,1977
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 500 umol/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 40,869,1984
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 500 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
20,2921,1971
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 500 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
20,2921,1971
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
21,1977,1972
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
21,1977,1972
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Fibroblast
DOSE/DURATION : 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 33,417,1975
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 5 mg/L
REFERENCE :
VAAZA2 Virchows Archiv, Abteilung B: Cell Pathology. (Springer-Verlag,
Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1968-
Volume(issue)/page/year: 27,79,1978
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 10 mg/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year:
47,157,1974
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 80 mg/kg
REFERENCE :
JJMCAQ Japanese Journal of Medical Science and Biology. (National Institute
of Health, 2-chome, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.5- 1952-
Volume(issue)/page/year: 38,207,1985
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 10 mg/L/30M (Continuous)
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 99,7,1976
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 10 mg/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year:
47,157,1974
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 10 mg/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year:
47,157,1974
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 41 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring
St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year:
27,95,1981
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 10 mg/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
Volume(issue)/page/year: 2,379,1986
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 75 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 15,2303,1994
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 45 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 94,449,1982
TYPE OF TEST : DNA adduct
TEST SYSTEM : Bird - wild bird species Leukocyte
DOSE/DURATION : 37500 nmol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year: 46,1399,1972
TYPE OF TEST : DNA damage
TEST SYSTEM : Bird - domestic Leukocyte
DOSE/DURATION : 1 mmol/L
REFERENCE :
NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246,
1971-73. For publisher information, see NATUAS. Volume(issue)/page/year:
243,20,1973
TYPE OF TEST : DNA damage
TEST SYSTEM : Bird - domestic Liver
DOSE/DURATION : 1 mmol/L
REFERENCE :
NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246,
1971-73. For publisher information, see NATUAS. Volume(issue)/page/year:
243,20,1973
TYPE OF TEST : DNA damage
TEST SYSTEM : Bird - domestic Cells - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246,
1971-73. For publisher information, see NATUAS. Volume(issue)/page/year:
243,20,1973
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 847 ug/kg
REFERENCE :
47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed.,
Totowa, NJ, Allanheld, Osmun & Co., 1982 Volume(issue)/page/year:
-,137,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1168
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 34 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1168
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 21 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: In vitro mammalian nonhuman micronucleus
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; Sperm
morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Inconclusive: Cytogenetics-male germ cell
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
NTP Carcinogenesis studies; selected, October 1997
*** END OF RECORD ***