*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SA9230000
CHEMICAL NAME           : 1-Pentanone,
                          5-methoxy-1-(4-(trifluoromethyl)phenyl)-,
                          O-(2-aminoethyl)oxime, (Z)-2-butenedioate (1:1)
CAS REGISTRY NUMBER     : 61718-82-9
LAST UPDATED            : 199701
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C15-H21-F3-N2-O2.C4-H4-O4
MOLECULAR WEIGHT        : 434.46
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Fluvoxamine maleate
   * 5-Methoxy-4'-trifluoromethylvalerophenone (E)-O-2-aminoethyloxime  
   monomaleate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 28,4149,1994
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 29120 mg/kg/13W-I
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Liver - changes in liver weight
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 28,4149,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 6825 mg/kg/13W-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in bladder weight
   Blood - changes in platelet count
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 28,4169,1994
 
                            *** END OF RECORD ***