*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SA6475000
CHEMICAL NAME           : 1-Pentanol, 2-(diethylamino)-4-methyl-,
                          p-aminobenzoate (ester), monomethanesulfonate
CAS REGISTRY NUMBER     : 135-44-4
LAST UPDATED            : 199012
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C17-H28-N2-O2.C-H4-O3-S
MOLECULAR WEIGHT        : 388.58
WISWESSER LINE NOTATION : ZR DVO1YN2&2&1Y1&1 &OSW1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * p-Aminobenzoic acid beta-diethylaminoisohexyl ester methanesulfonate
   * p-Aminobenzoic acid-N-1-diethylamino-1-isobutylethanol methanesulfonate
   * p-Aminobenzoic acid N,N-diethylleucinol ester methanesulfonate
   * N,N-Diethylleucinon-p-aminobenzoic acid methanesulfonate
   * 2-(Diethylamino)-4-methyl-1-pentanol, p-aminobenzoate ester,  
   methanesulfonate
   * Leucinocaine mesylate
   * Leucinocaine methanesulfonate
   * Methanesulfonic acid, compd. with 2-(diethylamino)-4-methylpentyl  
   P-aminobenzoate (1:1)
   * 2-Methyl-4-diethylaminopentan-5-ol p-aminobenzoate
   * Panthesin
   * Panthesine
   * S.P. 147
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 49 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
REFERENCE :
   WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische
   Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M.,
   Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger.
   Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 57,221,1936
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraspinal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 10200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 54,137,1935
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 112 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
                            *** END OF RECORD ***