*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SA1925000
CHEMICAL NAME : 2,4-Pentanedione
CAS REGISTRY NUMBER : 123-54-6
BEILSTEIN REFERENCE NO. : 0741937
REFERENCE : 4-01-00-03662 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 22
MOLECULAR FORMULA : C5-H8-O2
MOLECULAR WEIGHT : 100.13
WISWESSER LINE NOTATION : 1V1V1
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetoacetone
* Acetone, acetyl-
* Acetylacetone
* Acetyl 2-propanone
* Diacetylmethane
* Pentanedione
* Pentanedione-2,4
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 488 mg
REACTION SEVERITY : Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/8/1971
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mg
REACTION SEVERITY : Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 55 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - rigidity (including catalepsy)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 52(10),88,1987
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,343,1949
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
13,285,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 951 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4773,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 810 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 9,133,1986
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533573
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 gm/kg/2W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533731
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 805 ppm/6H/9D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,329,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 650 ppm/6H/14W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Brain and Coverings - changes in brain weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,329,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 6 gm/kg/12D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Spinal Cord - other degenerative changes
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533573
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 398 ppm/6H
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year:
6,461,1990
** MUTATION DATA **
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 694 ppm/6h/5D
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year:
5,463,1989
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 80 mg/L
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0386-0595
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84754
No. of Facilities: 221 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 3030 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84754
No. of Facilities: 350 (estimated)
No. of Industries: 9
No. of Occupations: 23
No. of Employees: 6171 (estimated)
No. of Female Employees: 1577 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***