*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RZ2620000
CHEMICAL NAME           : Pentaerythritol, tetranitrate
CAS REGISTRY NUMBER     : 78-11-5
OTHER CAS REGISTRY NOS. : 108736-71-6
BEILSTEIN REFERENCE NO. : 1716886
REFERENCE               : 4-01-00-02816 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C5-H8-N4-O12
MOLECULAR WEIGHT        : 316.17
WISWESSER LINE NOTATION : WNO1X1ONW1ONW1ONW
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Angicap
   * Angitet
   * Antora
   * Arcotrate
   * Baritrate
   * 2,2-Bis((nitrooxy)methyl)-1,3-propanediol dinitrate (ester)
   * 2,2-Bis(hydroxymethyl)-1,3-propanediol tetranitrate
   * CHOT
   * Deltrate-20
   * 1,3-Dinitrato-2,2-bis(nitratomethyl)propane
   * Duotrate
   * El PETN
   * Erinit
   * Hasethrol
   * Kaytrate
   * Lowetrate
   * Martrate-45
   * Metranil
   * Mikardol
   * Mycardol
   * Myotrate "10"
   * NCI-C55743
   * Neo-corovas
   * Neopentanetetrayl nitrate
   * Niperyt
   * Niperyth
   * Nitrinol
   * Nitropenta
   * Nitropentaerythrite
   * Nitropentaerythritol
   * Pencard
   * Pentafin
   * Pentanitrine
   * Pentarit
   * Pentestan-80
   * Pentetrate unicelles
   * Penthrit
   * Penthrite
   * Pentitrate
   * Pentrate
   * Pentriol
   * Pentritol
   * Pentryate
   * Pentryate 80
   * Pergitral
   * Peridex-LA
   * Peritrate
   * Perityl
   * PETN
   * Prevangor
   * 1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, dinitrate (ester)
   * Quintrate
   * Rythritol
   * SDM No. 23
   * SDM No. 35
   * Subicard
   * Tanipent
   * Tentrate-20
   * Tetranitropentaerythrite
   * Tetrasule
   * Tranite D-lay
   * Vasitol
   * Vasodiatol
   * Vaso-80 unicelies
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1669 mg/kg/8Y-C
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   BJDEAZ British Journal of Dermatology.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.63-    1951-  Volume(issue)/page/year: 87,498,1972
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRZKAP Farmatsevtichnii Zhurnal (Kiev).  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) V.3-    1930-  Volume(issue)/page/year: 16(2),63,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Vascular - regional or general arteriolar or venous dilation
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 131,187,1961
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12875 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Endocrine - thyroid tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-365,1989
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 160 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-365,1989

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83538
       No. of Facilities: 68 (estimated)
       No. of Industries: 1
       No. of Occupations: 6
       No. of Employees: 2770 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83538
       No. of Facilities: 59 (estimated)
       No. of Industries: 4
       No. of Occupations: 8
       No. of Employees: 2650 (estimated)
       No. of Female Employees: 1267 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NTP Carcinogenesis Studies (feed);equivocal evidence:rat
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-365,89

   NTP Carcinogenesis Studies (feed);no evidence:mouse
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-365,89

 
                            *** END OF RECORD ***