*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RY4375000
CHEMICAL NAME           : Penicillin
CAS REGISTRY NUMBER     : 1406-05-9
LAST UPDATED            : 199504
DATA ITEMS CITED        : 16
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Penizillin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 12385 ug/kg/16D-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 1,305,1947
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 5,1,1955
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 77,70,1943
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 77,70,1943
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 3,1663,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 3,1663,1978
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 72 mg/kg
SEX/DURATION            : female 13-15 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   BSFDA3 Bulletin de la Societe Francaise de Dermatologie et de
   Syphiligraphie.  (Paris, France) V.1-83, 1890-1976.  For publisher
   information, see ADVED7.  Volume(issue)/page/year: 57,534,1950

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   CLANA4 Clinical Anesthesia.  (Philadelphia, PA 19103)  V.1-11, 1963-76.
   Volume(issue)/page/year: 10(Pt 1),283,1973

   TOXICOLOGY REVIEW
   AVCPAY Advances in Clinical Pharmacology.  (Munich, Fed. Rep. Ger.) V.1-18,
   1969-78.  Volume(issue)/page/year: 8,6,1974

   TOXICOLOGY REVIEW
   MMWOAU Muenchener Medicinische Wochenschrift.  (Munich, Fed. Rep. Ger.)
   V.33-115, 1886-1973.  Volume(issue)/page/year: 115,1661,1973

   TOXICOLOGY REVIEW
   ADVPA3 Advances in Pharmacology.  (New York, NY)  V.1-6, 1962-68.  For
   publisher information, see AVPCAQ.  Volume(issue)/page/year: 4,263,1966

   TOXICOLOGY REVIEW
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 15,121,1976

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 54100
       No. of Facilities: 2090 (estimated)
       No. of Industries: 5
       No. of Occupations: 17
       No. of Employees: 11132 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 54100
       No. of Facilities: 780 (estimated)
       No. of Industries: 3
       No. of Occupations: 21
       No. of Employees: 25292 (estimated)
       No. of Female Employees: 15983 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; Sperm
   morphology-mouse
   
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay

 
                            *** END OF RECORD ***