*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RV0450000
CHEMICAL NAME           : Paraffin waxes and hydrocarbon waxes, chlorinated
CAS REGISTRY NUMBER     : 63449-39-8
LAST UPDATED            : 199710
DATA ITEMS CITED        : 14
COMPOUND DESCRIPTOR     : Primary Irritant
SYNONYMS/TRADE NAMES :
   * Cerechlor 54
   * Cereclor
   * Cereclor 30
   * Cereclor 42
   * Cereclor 48
   * Cereclor 52
   * Cereclor 54
   * Cereclor 70
   * Cereclor 51L
   * Cereclor 56L
   * Cereclor 63L
   * Cereclor 65L
   * Cereclor 70L
   * Cereclor 50LV
   * Cereclor S 42
   * Cereclor S52
   * Cereclor S70
   * Chlorcosane
   * Chlorez 700
   * Chlorez 700HMP
   * Chlorinated paraffins
   * Chloroparaffine 40G
   * Chlorowax
   * Chlorowax 40
   * Chlorowax 50
   * Chlorowax 70
   * Chlorowax 500C
   * Chlorowax 70S
   * Chlorowax S 70
   * Clorafin
   * Crechlor S 45
   * Flexchlor
   * NCI-C53587
   * Paroil chlorez
   * Unichlor
   * Unichlor 50
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   54,514,1980
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg
REACTION SEVERITY       : Mild
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   54,514,1980
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >21500 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 5,786,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >10 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 5,786,1979
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 mg/kg/90D-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in bladder weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   54,514,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 gm/kg/14D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Endocrine - other changes
   Biochemical - Effect on specific coenzyme - CoA
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 77,81,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3500 mg/kg/14D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Biochemical - Effect on specific coenzyme - CoA
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 77,81,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 9 gm/kg/90D-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   54,514,1980

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5417
       No. of Facilities: 27695 (estimated)
       No. of Industries: 202
       No. of Occupations: 119
       No. of Employees: 573193 (estimated)
       No. of Female Employees: 38354 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9112;8EHQ-0892-9113
   
   EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9114
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***