*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RT6460000
CHEMICAL NAME           : Palythoatoxin
CAS REGISTRY NUMBER     : 58718-68-6
LAST UPDATED            : 198308
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * PTX
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 ng/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - muscle contraction or spasticity
   Cardiac - other changes
REFERENCE :
   35FUAR "Animal, Plant, and Microbial Toxins, Proceedings of the
   International Symposium, 4th, 1974," Ohsaka, A., et al., eds., 2 vols., New
   York, Plenum Pub. Corp., 1976  Volume(issue)/page/year: 2,379,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 530 ng/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - muscle contraction or spasticity
   Cardiac - other changes
REFERENCE :
   35FUAR "Animal, Plant, and Microbial Toxins, Proceedings of the
   International Symposium, 4th, 1974," Ohsaka, A., et al., eds., 2 vols., New
   York, Plenum Pub. Corp., 1976  Volume(issue)/page/year: 2,379,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 200 ng/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - muscle contraction or spasticity
   Cardiac - other changes
REFERENCE :
   35FUAR "Animal, Plant, and Microbial Toxins, Proceedings of the
   International Symposium, 4th, 1974," Ohsaka, A., et al., eds., 2 vols., New
   York, Plenum Pub. Corp., 1976  Volume(issue)/page/year: 2,379,1976
 
                            *** END OF RECORD ***