*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : RS8225000
CHEMICAL NAME : Ozone
CAS REGISTRY NUMBER : 10028-15-6
LAST UPDATED : 199712
DATA ITEMS CITED : 97
MOLECULAR FORMULA : O3
MOLECULAR WEIGHT : 48.00
WISWESSER LINE NOTATION : O3
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Ozon
* Ozone
* Triatomic oxygen
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 ppm/4H
REFERENCE :
JPCAAC Journal of the Air Pollution Control Association. (Air Pollution
Control Assoc., POB 2861, Pittsburgh, PA 15230) V.5- 1955-
Volume(issue)/page/year: 10,17,1960
** ACUTE TOXICITY DATA **
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 50 ppm/30M
TOXIC EFFECTS :
Behavioral - headache
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,446,1969
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 80 ppb/6.6H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - respiratory depression
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
46,145,1991
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 100 ppm/1M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NEACA9 News Edition, American Chemical Society. (Easton, PA) V.18-19,
1940-41. For publisher information, see CENEAR. Volume(issue)/page/year:
19,686,1941
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1860 ppb/75M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Cardiac - pulse rate
Lungs, Thorax, or Respiration - cough
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
10,517,1965
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 1 ppm
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
10,295,1965
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 600 ppb/2H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740
Broadway, New York, NY 10019) V.80- 1959- Volume(issue)/page/year:
118,287,1978
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4800 ppb/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 15,181,1957
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 12600 ppb/3H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 16,22,1957
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 34500 ppb/3H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year:
25,301,1956
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 36 ppm/3H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year:
25,301,1956
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 24800 ppb/3H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year: 26,63,1957
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 10500 ppb/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 15,181,1957
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 950 ppb/8H/90D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
106,384,1990
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1600 ug/m3/24H/7D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Lungs, Thorax, or Respiration - changes in lung weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 24,515,1988
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 800 ug/m3/24H/3D-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
116,209,1992
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 700 ppb/2H/28D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 17,143,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 ppb/24H/12W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - cytochrome oxidases (including oxidative phosphorylation)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 42,425,1987
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 750 ppb/24H/14D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Blood - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 3(5-6),247,1980
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 ppb/24H/14D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Endocrine - changes in thymus weight
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 35,490,1984
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 ppm/24H/4W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Immunological Including Allergic - decrease in humoral immune response
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology.
(Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
Volume(issue)/page/year: 9,243,1989
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 608 ug/m3/26W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 26,139,1985
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 1500 pph/8H/21D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 29,207,1985
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 400 ppb/8H/90D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Lungs, Thorax, or Respiration - fibrosis (interstitial)
REFERENCE :
EXLRDA Experimental Lung Research. (Hemisphere Publishing, c/o Taylor &
Francis 1900 Frost Road, Suite 101, Bristol, PA 19007) V.1- 1980-
Volume(issue)/page/year: 12,57,1987
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 ppb/2H/13D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 21,27,1987
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2 ppm/2D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Lungs, Thorax, or Respiration - changes in lung weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 3,521,1977
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 800 ug/m3/24H/3D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
116,209,1992
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 3 mg/m3/24H/7D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 54,39,1991
** TUMORIGENIC DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 ppm/2H/75D-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
20,16,1970
TYPE OF TEST : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 608 ug/m3/24W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 75,771,1985
TYPE OF TEST : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-440,1994
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 1040 ppb/24H
SEX/DURATION : female 6-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
48,19,1979
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 1500 ppb/24H
SEX/DURATION : female 17-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - physical
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 5,3,1980
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 19 ppb/35M
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
17(Suppl 19),22,1991
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 3 mg/L
REFERENCE :
OZSEDS Ozone: Science & Engineering. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1979- Volume(issue)/page/year:
8,217,1986
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 50 ppm
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
Volume(issue)/page/year: 197,472,1984
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 50 ppm/30M
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year: 77,220,1977
TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 500 ug/L
REFERENCE :
AIPAAV Annales de l'Institut Pasteur (Paris). (Paris, France) V.1-123,
1887-1972. For publisher information, see ANMBCM. Volume(issue)/page/year:
114,595,1968
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 50 ppm
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 26,706,1984
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 70 pph
REFERENCE :
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1901- Volume(issue)/page/year: 78,199,1977
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 30 ppm/3H (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,657,1982
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Human
DOSE/DURATION : 500 ppb/6H
REFERENCE :
MEHYDY Medical Hypotheses. (Churchill Livingstone Inc., 1560 Broadway, New
York, NY 10036) V.1- 1975- Volume(issue)/page/year: 4,165,1978
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 7230 ppb/1H
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 12,188,1976
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 8 ppm/5M (Continuous)
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 194,793,1962
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lung
DOSE/DURATION : 250 ppb/1H (Continuous)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 18,336,1979
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 28 mg/m3/5D (Continuous)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 44(9),12,1979
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Fibroblast
DOSE/DURATION : 5 ppm
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 7,1611,1986
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Fibroblast
DOSE/DURATION : 25 mmol/L
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce
Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year:
247,69,1987
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 5 ppm
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 7,1611,1986
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 2 ppm/1H
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 17,119,1986
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 200 ppb/5H
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 4,262,1971
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Bird - chicken Fibroblast
DOSE/DURATION : 1 ug/L/30M
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75,
1903-71. For publisher information, see JCROD7. Volume(issue)/page/year:
67,113,1965
*** REVIEWS ***
ACGIH TLV-TWA 0.20 mg/m3 (0.1 ppm), light work
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.16 mg/m3 (0.08 ppm), mod work
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997
ACGIH TLV-TWA 0.1 mg/m3 (0.05 ppm), heavy work
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997
TOXICOLOGY REVIEW
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 35,89,1976
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB228-002
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
16,903,1968
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: CONF-691001
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.1 ppm (0.2 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,194,1971
OSHA PEL (Gen Indu):8H TWA 0.1 ppm (0.2 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.1 ppm (0.2 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.1 ppm (0.2 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 ppm (0.2 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.1 ppm (0.02 mg/m3) JAN 1993
OEL-AUSTRALIA:TWA 0.1 ppm (0.2 mg/m3);STEL 0.3 ppm (0.6 mg/m3) JAN 1993
OEL-BELGIUM:STEL 0.1 ppm (0.2 mg/m3) JAN 1993
OEL-DENMARK:TWA 0.1 ppm (0.2 mg/m3) JAN 1993
OEL-FINLAND:TWA 0.1 ppm (0.2 mg/m3);STEL 0.3 ppm (0.6 mg/m3) JAN 1993
OEL-FRANCE:TWA 0.1 ppm (0.2 mg/m3);STEL 0.2 ppm (0.4 mg/m3) JAN 1993
OEL-GERMANY:TWA 0.1 ppm (0.2 mg/m3) JAN 1993
OEL-HUNGARY:TWA 0.2 mg/m3;STEL 0.4 mg/m3 JAN 1993
OEL-JAPAN:TWA 0.1 ppm (0.2 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 ppm (0.2 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 ppm (0.2 mg/m3) JAN 1993
OEL-POLAND:TWA 0.1 mg/m3 JAN 1993
OEL-RUSSIA:TWA 0.1 ppm;STEL 0.1 mg/m3 JAN 1993
OEL-SWEDEN:TWA 0.1 ppm (0.2 mg/m3);STEL 0.3 ppm (0.6 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (0.2 mg/m3);STEL 0.2 ppm (0.4 mg/m3) JAN 1993
OEL-TURKEY:TWA 0.1 ppm (0.2 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 ppm (0.2 mg/m3);STEL 0.3 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO OZONE-air:CL 0.1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81651
No. of Facilities: 6329 (estimated)
No. of Industries: 54
No. of Occupations: 53
No. of Employees: 32552 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81651
No. of Facilities: 5347 (estimated)
No. of Industries: 70
No. of Occupations: 67
No. of Employees: 72134 (estimated)
No. of Female Employees: 32361 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone
marrow
EPA GENETOX PROGRAM 1988, Negative: In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-nonhuman
lymphocyte
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro cytogenetics-human
lymphocyte
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-human
lymphocyte
EPA GENETOX PROGRAM 1988, Inconclusive: Cytogenetics-male germ cell
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis Studies (inhalation);some evidence:mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-440,94
NTP Carcinogenesis Studies (inhalation);no evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-440,94
*** END OF RECORD ***