*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RR0390000
CHEMICAL NAME           : Oxiranecarboxylic acid,
                          3-(((1-(((4-((aminoiminomethyl)amino)butyl)amino)carb
                          onyl)-3-methyl butyl)amino)carbonyl)-,
                          (2S-(2-alpha,3-beta(R*)))-
CAS REGISTRY NUMBER     : 66701-25-5
BEILSTEIN REFERENCE NO. : 1405664
REFERENCE               : 5-18-07-00006 (Beilstein Handbook Reference)
LAST UPDATED            : 199806
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C15-H27-N5-O5
MOLECULAR WEIGHT        : 357.47
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * E 64
   * E 64 (proteinase inhibitor)
   * Proteinase inhibitor E 64
   * Thiol protease inhibitor
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 9-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   APDJBE Acta Paediatrica Japonica (Overseas Edition).  (Societas Pediatrica
   Japonica, 1-1-5-Koraku, Bunkyo-ku, Tokyo, 112, Japan)  V.1-  1958-
   Volume(issue)/page/year: 32,495,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 9-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   APDJBE Acta Paediatrica Japonica (Overseas Edition).  (Societas Pediatrica
   Japonica, 1-1-5-Koraku, Bunkyo-ku, Tokyo, 112, Japan)  V.1-  1958-
   Volume(issue)/page/year: 32,495,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   KDIZAA Kagoshima Daigaku Igaku Zasshi.  Medical Journal of Kagoshima
   University.  (Kagoshima Daigaku Igakkai, 1208-1, Usuki-cho, Kagoshima 890,
   Japan)  V.1-   1945-  Volume(issue)/page/year: 48,1,1996
 
                            *** END OF RECORD ***