*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RQ3630000
CHEMICAL NAME           : 2-Oxazolidinone,
                          5-(morpholinomethyl)-3-((5-nitrofurfurylidene)amino)-
                          , monohydrochloride
CAS REGISTRY NUMBER     : 3759-92-0
LAST UPDATED            : 199410
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C13-H16-N4-O6.Cl-H
MOLECULAR WEIGHT        : 360.79
WISWESSER LINE NOTATION : T6N DOTJ A1- ET5NVOTJ ANU1- BT5OJ ENW &GH
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Furaltadone hydrochloride
   * 5-Morpholinomethyl-3-(5-nitrofurfurylidine)amino-2-oxazolidinone  
   hydrochloride
   * NF-269
   * NF-902 hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - respiratory depression
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 16,663,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 190 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - respiratory depression
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 16,663,1964
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 umol/L
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 75,424,1978

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion

 
                            *** END OF RECORD ***