*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP5776500
CHEMICAL NAME           : Oxayohimban-16-carboxylic acid,
                          16,17-didehydro-10,11-dimethoxy-19-methyl-, methyl
                          ester
CAS REGISTRY NUMBER     : 3148-42-3
LAST UPDATED            : 198306
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C23-H28-N2-O5
MOLECULAR WEIGHT        : 412.53
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Dimethoxy-10,11 carbomethoxy-16 hetero  
   yohimbane-3-alpha,15-alpha,19-alpha,20-beta
   * 10,11-Dimethoxy-19-methyl-16,17-didehydrooxayohimban-16-carboxylic acid  
   methyl ester
   * Rauvanin
   * Rauvanine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 157 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Behavioral - antipsychotic
   Behavioral - alteration of operant conditioning
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 30,45,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 30,81,1972
 
                            *** END OF RECORD ***