*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP6471000
CHEMICAL NAME           : 2H-1,3-Oxazine-2-thione,
                          3,4,5,6-tetrahydro-6-phenoxymethyl-
CAS REGISTRY NUMBER     : 39754-64-8
BEILSTEIN REFERENCE NO. : 0517442
LAST UPDATED            : 199712
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C11-H13-N-O2-S
MOLECULAR WEIGHT        : 223.31
WISWESSER LINE NOTATION : T6MYOTJ BUS D1OR
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2H-1,3-Oxazine-2-thione, 6-phenoxymethyl-3,4,5,6-tetrahydro-
   * 6-Phenoxymethyl-3,4,5,6-tetrahydro-2H-1,3-oxazine-2-thione
   * Phenoxymethyl-6 tetrahydroxazine-1,3 thione-2
   * Tetrahydro-6-(phenoxymethyl)-2H-1,3-oxazine-2-thione
   * Tifemoxone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Kidney, Ureter, Bladder - urine volume increased
   Blood - normocytic anemia
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 1,229,1978
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 11,75,1976
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15470 mg/kg/26W-I
TOXIC EFFECTS :
   Behavioral - aggression
   Skin and Appendages - hair
   Related to Chronic Data - death
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 1,229,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 10010 ug/kg/26W-I
TOXIC EFFECTS :
   Liver - liver function tests impaired
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 1,229,1978
 
                            *** END OF RECORD ***