*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP6152100
CHEMICAL NAME           : 2H-1,3,2-Oxazaphosphorine,
                          tetrahydro-2-(bis(2-chloroethyl)amino)-4-methyl-,
                          2-oxide
CAS REGISTRY NUMBER     : 52663-82-8
LAST UPDATED            : 199404
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C8-H17-Cl2-N2-O2-P
MOLECULAR WEIGHT        : 275.14
WISWESSER LINE NOTATION : T6MPOTJ BO BN2G2G F1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * B 699
   * 4-Methylcyclophosphamide
   * Tetrahydro-2-(bis(2-chloroethyl)amino)-4-methyl-2H-1,3,2-oxazaphosphorine 
    2-oxide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,143,1961
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bird - chicken Cells - not otherwise specified
DOSE/DURATION           : 10500 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 268,115,1992
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Bird - chicken Cells - not otherwise specified
DOSE/DURATION           : 1310 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 268,115,1992
 
                            *** END OF RECORD ***