*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP6151200
CHEMICAL NAME           : 2H-1,3,2-Oxazaphosphorine,
                          tetrahydro-2-(bis(2-chloroethyl)amino)-5-fluoro-,
                          2-oxide, (Z)-
CAS REGISTRY NUMBER     : 78542-59-3
LAST UPDATED            : 198906
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C7-H14-Cl2-F-N2-O2-P
MOLECULAR WEIGHT        : 279.10
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   cis-2-(Bis(2-chloroethyl)amino)-5-fluorotetrahydro-2H-1,3,2-oxazaphospho
     rine
   * cis-5-Fluorocyclophosphamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 24,1399,1981
 
                            *** END OF RECORD ***