*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP5965000
CHEMICAL NAME           : 2H-1,3,2-Oxazaphosphorine,
                          2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide, and
                          1-methyl-1-nitrosourea (2:1)
SUBSTANCE DEFINITION :
   The combination of these two drugs is used in chemotherapy to combat far
   advanced malignant tumors
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
LAST UPDATED            : 199506
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C7-H15-Cl2-N2-O2-P.C4-H5-N6-O2
MOLECULAR WEIGHT        : 430.26
WISWESSER LINE NOTATION : T6MPOTJ BO BN2G2G &ZVN1&NO
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Cyclophosphamide and MNU (1:2)
   * MNU and cyclophosphamide (2:1)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 48 mg/kg/28D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - changes in bone marrow (not otherwise specified)
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 89,311,1977
 
                            *** END OF RECORD ***