*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP5789000
CHEMICAL NAME           : 2H-1,3,2-Oxazaphosphorin-2-amine,
                          N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (+-)-
LAST UPDATED            : 198812
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C9-H18-Cl3-N2-O2-P
MOLECULAR WEIGHT        : 323.61
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (+-)-N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 
    2-oxide
   * D,L-Trofosfamide
   * (+-)-Trofosphamide
   * (R,S)-Trofosphamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1050 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   34,305,1986
 
                            *** END OF RECORD ***