*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP5788700
CHEMICAL NAME           : 2H-1,3,2-Oxazaphosphorin-2-amine,
                          tetrahydro-N,N-diethyl-, 2-oxide
CAS REGISTRY NUMBER     : 53859-37-3
BEILSTEIN REFERENCE NO. : 1073314
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C7-H17-N2-O2-P
MOLECULAR WEIGHT        : 192.23
WISWESSER LINE NOTATION : T6MPOTJ BO BN2&2
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * ASTA 7019
   * ASTA B 516
   * B 516
   * Didechlorocyclophosphamide
   * 2-(Diethylamino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
   * 2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(diethylamino)-, 2-oxide
   * Tetrahydro-2-(diethylamino)-2H-1,3,2-oxazaphosphorine 2-oxide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,143,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 60,477,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Bird - chicken Cells - not otherwise specified
DOSE/DURATION           : 211 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 268,115,1992
 
                            *** END OF RECORD ***