*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP5788693
CHEMICAL NAME           : 2H-1,3,2-Oxazaphosphorin-2-amine,
                          tetrahydro-N,3-bis(2-chloroethyl)-, 2-oxide, (R)-
CAS REGISTRY NUMBER     : 66849-34-1
BEILSTEIN REFERENCE NO. : 5802894
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C7-H15-Cl2-N2-O2-P
MOLECULAR WEIGHT        : 261.11
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (R)-N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine  
   2-oxide
   * (+)-Ifosfamide
   * (+)-Ifosphamide
   * L-Ifosfamide
   * (R)-Tetrahydro-N,3-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine  
   2-oxide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2800 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   34,293,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   34,293,1986
 
                            *** END OF RECORD ***