*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RO0720000
CHEMICAL NAME           : 1,2,4-Oxadiazole,
                          5-(2-(diethylamino)ethyl)-3-phenyl-, citrate
CAS REGISTRY NUMBER     : 1949-20-8
LAST UPDATED            : 199712
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C14-H19-N3-O.C6-H8-O7
MOLECULAR WEIGHT        : 437.50
WISWESSER LINE NOTATION : T5NO DNJ C2N2&2 ER &QV1XQVQ1VQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Oxolamine citrate
   * 5-beta-Diethylaminoethyl-3-phenyl-1,2,4-oxadiazole citrate
   * 3-Phenyl-5-(beta-(diethylamino)ethyl)-1,2,4-oxadiazole citrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 16,209,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 351 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMXXAJ French Medicament Patent Document.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Discontinued.
   Volume(issue)/page/year: #683M
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 19,631,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 351 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 16,209,1961
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 43400 mg/kg/7W-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in kidney weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   EMPSAL Experimental and Molecular Pathology, Supplement.  (New York, NY)
   No.1-3, 1963-66. Discontinued.  Volume(issue)/page/year: 2,1,1963
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 7177 mg/kg/7W-I
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of salivary glands
   Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   EMPSAL Experimental and Molecular Pathology, Supplement.  (New York, NY)
   No.1-3, 1963-66. Discontinued.  Volume(issue)/page/year: 2,1,1963
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 gm/kg/1Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   EMPSAL Experimental and Molecular Pathology, Supplement.  (New York, NY)
   No.1-3, 1963-66. Discontinued.  Volume(issue)/page/year: 2,1,1963
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 120 mg/kg
SEX/DURATION            : female 9-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,781,1967
 
                            *** END OF RECORD ***