*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RO0548600
CHEMICAL NAME           : 1,3,4-Oxadiazol-2-amine, 5-phenyl-, monohydrochloride
CAS REGISTRY NUMBER     : 1905-75-5
LAST UPDATED            : 199203
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C8-H7-N3-O.Cl-H
MOLECULAR WEIGHT        : 197.64
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2-Amino-5-phenyl-1,3,4-oxadiazole hydrochloride
   * delta(sup 2)-1,3,4-Oxadiazoline, 5-imino-2-phenyl-, monohydrochloride
   * 5-Phenyl-1,3,4-oxadiazol-2-amine hydrochloride
   * SQ 4573
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,726,1961
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,726,1961
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >60 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,726,1961
 
                            *** END OF RECORD ***