*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RN6802000
CHEMICAL NAME           : 3-Oxa-9-aza-6-azoniaspiro(5.5)undecane,
                          9-((4-chlorophenyl)phenylmethyl)-, chloride,
                          hydrochloride
CAS REGISTRY NUMBER     : 55981-23-2
LAST UPDATED            : 198208
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C21-H26-Cl-N2-O.Cl.Cl-H
MOLECULAR WEIGHT        : 429.85
WISWESSER LINE NOTATION : T6K DOTJ A-& AT6K DNTJ DYR&R DG &GH &G
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N(sup 1)-(4'-Chlorobenzhydryl)-N(sup 4)-spiromorpholino-piperazinium  
   chloride hydrochloride
   * 9-((4-Chlorophenyl)phenylmethyl)-3-oxa-9-aza-6-azoniaspiro(5.5)undecane  
   chloride HCl
   * CRC 7001
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40500 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   APJUA8 Acta Pharmaceutica Jugoslavica.  (FDH, Masarykova 2, 41000 Zagreb,
   Yugoslavia)  V.1-41, 1951-1991.  Volume(issue)/page/year: 28,21,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2400 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   APJUA8 Acta Pharmaceutica Jugoslavica.  (FDH, Masarykova 2, 41000 Zagreb,
   Yugoslavia)  V.1-41, 1951-1991.  Volume(issue)/page/year: 28,21,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   APJUA8 Acta Pharmaceutica Jugoslavica.  (FDH, Masarykova 2, 41000 Zagreb,
   Yugoslavia)  V.1-41, 1951-1991.  Volume(issue)/page/year: 28,21,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51300 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   APJUA8 Acta Pharmaceutica Jugoslavica.  (FDH, Masarykova 2, 41000 Zagreb,
   Yugoslavia)  V.1-41, 1951-1991.  Volume(issue)/page/year: 28,21,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3300 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   APJUA8 Acta Pharmaceutica Jugoslavica.  (FDH, Masarykova 2, 41000 Zagreb,
   Yugoslavia)  V.1-41, 1951-1991.  Volume(issue)/page/year: 28,21,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 281 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   APJUA8 Acta Pharmaceutica Jugoslavica.  (FDH, Masarykova 2, 41000 Zagreb,
   Yugoslavia)  V.1-41, 1951-1991.  Volume(issue)/page/year: 28,21,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 315 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   APJUA8 Acta Pharmaceutica Jugoslavica.  (FDH, Masarykova 2, 41000 Zagreb,
   Yugoslavia)  V.1-41, 1951-1991.  Volume(issue)/page/year: 28,21,1978
 
                            *** END OF RECORD ***