*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RN6800500
CHEMICAL NAME           : 4-Oxa-5-alpha-androstan-3-one,
                          6-alpha-bromo-17-beta-hydroxy-17-methyl-
CAS REGISTRY NUMBER     : 24543-59-7
LAST UPDATED            : 198910
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C19-H29-Br-O3
MOLECULAR WEIGHT        : 385.39
WISWESSER LINE NOTATION : T E5 B666 NOVTJ A1 E1 FQ F1 LE
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * BOMT
   *   6-alpha-Bromo-17-beta-hydroxy-17-alpha-methyl-4-oxa-5-alpha-androstan-3-
     one
   * 6-alpha-Bromo-17-beta-methyl-4-oxa-5-alpha-androstan-3-one
   * 4-Oxaandrostan-3-one, 6-bromo-17-hydroxy-17-methyl-,  
   (5-alpha,6-alpha,17-beta)-
   * Ro 7-2340
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : female 14-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.
   (SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987.  For publisher
   information,  see BSTME2.  Volume(issue)/page/year: 63,239,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3500 mg/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.
   (SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987.  For publisher
   information,  see BSTME2.  Volume(issue)/page/year: 63,239,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.
   (SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987.  For publisher
   information,  see BSTME2.  Volume(issue)/page/year: 63,239,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 350 mg/kg
SEX/DURATION            : female 14-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.
   (SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987.  For publisher
   information,  see BSTME2.  Volume(issue)/page/year: 63,239,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1750 mg/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.
   (SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987.  For publisher
   information,  see BSTME2.  Volume(issue)/page/year: 63,239,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1750 mg/kg
SEX/DURATION            : female 14-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - skin and skin
   appendages
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.
   (SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987.  For publisher
   information,  see BSTME2.  Volume(issue)/page/year: 64,27,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 350 mg/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.
   (SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987.  For publisher
   information,  see BSTME2.  Volume(issue)/page/year: 63,239,1974
 
                            *** END OF RECORD ***