*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RF4400000
CHEMICAL NAME           : Nutmeg
CAS REGISTRY NUMBER     : 84082-68-8
LAST UPDATED            : 199103
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Human
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Myristica
   * Nuces nucistae
   * Nux moschata
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in REM sleep (human)
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
   2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan)  V.1-   1988-
   Volume(issue)/page/year: 2,169,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 214 mg/kg
TOXIC EFFECTS :
   Behavioral - euphoria
   Behavioral - hallucinations, distorted perceptions
   Cardiac - change in rate
REFERENCE :
   JNEUAY Journal of Neuropsychiatry.  (Chicago, IL)  V.1-5, 1959-64.  For
   publisher information, see BENPBG.  Volume(issue)/page/year: 2,205,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNEUAY Journal of Neuropsychiatry.  (Chicago, IL)  V.1-5, 1959-64.  For
   publisher information, see BENPBG.  Volume(issue)/page/year: 2,205,1961

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   PISDDJ Pacific Information Service on Street Drugs.  (J.K. Brown, School of
   Pharmacy, Univ. of the Pacific, Stockton, CA 95211)  V.1-    1972(?)-
   Volume(issue)/page/year: 5(3-6),-,1977

   TOXICOLOGY REVIEW
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 12,1,1978

 
                            *** END OF RECORD ***