*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RF0760000
CHEMICAL NAME           : Nuclease, ribo-
CAS REGISTRY NUMBER     : 9001-99-4
LAST UPDATED            : 199701
DATA ITEMS CITED        : 10
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Alkaline ribonuclease
   * E.C. 2.7.7.16
   * E.C. 3.1.4.22
   * Pancreatic ribonuclease
   * Ribonuclease
   * Ribonuclease A
   * Ribonuclease I
   * Ribonucleic phosphatase
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 392 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
   Nucleases: Biological Function and Practical Applications," Berdyshev, G.D.,
   et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
   Volume(issue)/page/year: -,56,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
   Nucleases: Biological Function and Practical Applications," Berdyshev, G.D.,
   et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
   Volume(issue)/page/year: -,56,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
   Nucleases: Biological Function and Practical Applications," Berdyshev, G.D.,
   et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
   Volume(issue)/page/year: -,56,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
   Nucleases: Biological Function and Practical Applications," Berdyshev, G.D.,
   et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
   Volume(issue)/page/year: -,56,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
   Nucleases: Biological Function and Practical Applications," Berdyshev, G.D.,
   et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
   Volume(issue)/page/year: -,56,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 355 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
   Nucleases: Biological Function and Practical Applications," Berdyshev, G.D.,
   et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
   Volume(issue)/page/year: -,56,1985
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 40 mg/L
REFERENCE :
   AMICCW Archives of Microbiology.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secacus, NJ 07094)  V.95-    1974-
   Volume(issue)/page/year: 122,161,1979
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 40 mg/L
REFERENCE :
   AMICCW Archives of Microbiology.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secacus, NJ 07094)  V.95-    1974-
   Volume(issue)/page/year: 122,161,1979
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 40 mg/L
REFERENCE :
   AMICCW Archives of Microbiology.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secacus, NJ 07094)  V.95-    1974-
   Volume(issue)/page/year: 122,161,1979

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***