*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RD4200000
CHEMICAL NAME           : Nourseothricin, hydrochloride
LAST UPDATED            : 198812
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Drug
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 690 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   AXVMAW Archiv fuer Experimentelle Veterinaermedizin.  (S. Hirzel Verlag,
   Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.)  V.6-    1952-
   Volume(issue)/page/year: 40,727,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15600 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   AXVMAW Archiv fuer Experimentelle Veterinaermedizin.  (S. Hirzel Verlag,
   Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.)  V.6-    1952-
   Volume(issue)/page/year: 40,727,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1150 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   AXVMAW Archiv fuer Experimentelle Veterinaermedizin.  (S. Hirzel Verlag,
   Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.)  V.6-    1952-
   Volume(issue)/page/year: 40,727,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23800 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   AXVMAW Archiv fuer Experimentelle Veterinaermedizin.  (S. Hirzel Verlag,
   Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.)  V.6-    1952-
   Volume(issue)/page/year: 40,727,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14600 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   AXVMAW Archiv fuer Experimentelle Veterinaermedizin.  (S. Hirzel Verlag,
   Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.)  V.6-    1952-
   Volume(issue)/page/year: 40,727,1986
 
                            *** END OF RECORD ***