*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RD2535000
CHEMICAL NAME           : C'-Norvincaleukoblastine, 3',4'-didehydro-4'-dioxy-,
                          (R-(R*,R*))-2,3- dihydroxybutanedioate (1:2)
CAS REGISTRY NUMBER     : 125317-39-7
LAST UPDATED            : 199706
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C45-H54-N4-O8.2C4-H6-O6
MOLECULAR WEIGHT        : 1079.23
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * KW-2307
   * Vinorelbine ditartrate
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 mg/kg
SEX/DURATION            : female 7-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 27,1375,1993
 
                            *** END OF RECORD ***