*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RC8964500
CHEMICAL NAME           : 19-Nor-17-alpha-pregn-4-en-20-yn-17-ol mixed with
                          3-methoxy-19-nor-17-alpha-pregna-
                          1,3,5(10)-trien-20-yn-17-ol
CAS REGISTRY NUMBER     : 8015-14-3
LAST UPDATED            : 199304
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C21-H26-O2.C20-H28-O
MOLECULAR WEIGHT        : 594.95
WISWESSER LINE NOTATION : L E5 B666TTT&J E1 FQ F1UU1 OO1 &L E5 B666 MUTJ E1 FQ
                          F1UU1
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Lyndiol
   * Lynestrenol mixed with mestranol
   * Lynoestrenol mixed with mestranol
   * Lynestrol mixed with mestranol
   * Mestranol mixed with lynestrenol
   * Mestranol mixed with lynestrol
   * Noracycline
   * Ovanon
   * Ovariostat
   * Restovar
   * Sistometrenol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 22 mg/kg/2Y-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,1479,1973
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 32 mg/kg/130W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 2,223,1978
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 104 mg/kg/10Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 2,223,1978
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 91 mg/kg/7Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   NPMDAD Nouvelle Presse Medicale.  (Paris, France)  V.1-11, 1972-82.
   Volume(issue)/page/year: 5,3014,1976
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 34 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   HEGAD4 Hepato-gastroenterology.  (Georg Thieme Verlag, Postfach 732, D-7000
   Stuttgart 1, Fed. Rep. Ger.)  V.27-    1980-  Volume(issue)/page/year:
   29,187,1982
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 75 mg/kg
SEX/DURATION            : female 1-5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   INDRBA Indian Drugs.  (Indian Drugs Manufacturers' Assoc., 102B, Poonam
   Chambers, Dr. A. B. Rd., Worli, Bombay 400 018, India)  V.1-    1963-
   Volume(issue)/page/year: 21,141,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 25 mg/kg
SEX/DURATION            : female 1-5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   INDRBA Indian Drugs.  (Indian Drugs Manufacturers' Assoc., 102B, Poonam
   Chambers, Dr. A. B. Rd., Worli, Bombay 400 018, India)  V.1-    1963-
   Volume(issue)/page/year: 21,141,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 649 ug/kg
SEX/DURATION            : female 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   IRLCDZ IRCS Medical Science: Library Compendium.  (Lancaster, UK)  V.3-11,
   1975-83. For publisher information, see IMSCE2.  Volume(issue)/page/year:
   6,307,1978

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal

 
                            *** END OF RECORD ***