*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RC8960750
CHEMICAL NAME           : 19-Norpregn-4-ene-3,20-dione,
                          17-hydroxy-16-methylene-, acetate
CAS REGISTRY NUMBER     : 7759-35-5
LAST UPDATED            : 199306
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C23-H30-O4
MOLECULAR WEIGHT        : 370.53
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Human
                          Hormone
SYNONYMS/TRADE NAMES :
   * 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate
   * 16-Methylene-17-alpha-acetoxy-19-nor-4-pregnene-3,20-dione
   * 19-Norpregn-4-ene-3,20-dione, 17-(acetyloxy)-16-methylene-
   * ST-1435
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Human - woman
DOSE                    : 240 ug/kg
SEX/DURATION            : female 24 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 58,680,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Human - woman
DOSE                    : 800 ug/kg
SEX/DURATION            : female 56 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 25,299,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Human - woman
DOSE                    : 2200 ug/kg
SEX/DURATION            : female 43 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 18,411,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Human - woman
DOSE                    : 700 ug/kg
SEX/DURATION            : female 26 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 36,737,1981
 
                            *** END OF RECORD ***