*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RC8945400
CHEMICAL NAME           : 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol,
                          (17-alpha)-, mixt. with (17-alpha)-
                          19-norpregn-4-en-20-yn-17-ol
CAS REGISTRY NUMBER     : 8064-76-4
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H28-O.C20-H24-O2
MOLECULAR WEIGHT        : 580.92
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Ba 49249
   * C 49249Ba
   * Ethynylestradiol-lynestrenol mixt.
   * Ethinyloestradiol mixt. with lynoestrenol
   * Fisioquens
   * Fysioquens
   * Lynoestrenol mixt. with ethinyloestradiol
   * Minilyn
   * Ovostat
   * Ovostat 1375
   * Ovostat E
   * Yermonil
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 77112 ug/kg/6Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - jaundice, other or unclassified
   Liver - tumors
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,273,1980
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 4284 ug/kg
SEX/DURATION            : female 84 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,487,1977
 
                            *** END OF RECORD ***