*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RC6311000
CHEMICAL NAME           : L-Norleucine,
                          6-diazo-N-(6-diazo-N-L-gamma-glutamyl-5-oxo-L-norleuc
                          yl)-5-oxo-, sodium salt
CAS REGISTRY NUMBER     : 55156-24-6
LAST UPDATED            : 199509
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C17-H23-N7-O8.xNa
MOLECULAR WEIGHT        : 614.40
WISWESSER LINE NOTATION : QVYZ2VMY2V1UNN&VMYVQ2V1UNN &-NA-
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * A 10270B
   * Antibiotic 1719 sodium salt
   * Azotomycin sodium
   * Azotomycin sodium salt
   * Glutamine,  
   N-(1-((1-carboxy-5-diazo-4-oxopentyl)carbamoyl)-5-diazo-4-oxopentyl)-,  
   sodium salt
   * Hexanoic acid,  
   6-diazo-2-(2-(4-amino-4-carboxybutyramido)-6-diazo-5-oxohexanamido)-,  
   sodium
   * NSC 56654
   * 1719 Sodium
   * Sodium azotomycin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 388 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 262 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Liver - other changes
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   23,3467,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 271 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4300 ug/kg/5D-I
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of endocrine pancreas
   Biochemical - Metabolism (Intermediary) - amino acids (including renal
   excretion)
   Related to Chronic Data - death
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   23,3467,1974
 
                            *** END OF RECORD ***