*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RC1300000
CHEMICAL NAME           : 20-Norcrotalanan-11,15-dione,
                          14,19-dihydro-13-hydroxy-, (12-xi,13-xi)-
CAS REGISTRY NUMBER     : 6029-87-4
BEILSTEIN REFERENCE NO. : 1088365
LAST UPDATED            : 199712
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C16-H23-N-O5
MOLECULAR WEIGHT        : 309.40
WISWESSER LINE NOTATION : T55-11- 1A P EN IOV NVO BUTJ K1 LQ L1 M1
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Crispatine
   * 13-Epicrispatine
   * Fulvine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PAREAQ Pharmacological Reviews.  (Williams & Wilkins, 428 E. Preston St.,
   Baltimore, MD 21202) V.1-    1949-  Volume(issue)/page/year: 22,429,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   28,2237,1968
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 mg/kg
SEX/DURATION            : female 9-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   EXPTAX Experimentelle Pathologie (1967-1980).  (Jena, Ger. Dem. Rep.)
   V.1-18, 1967-80.  For publisher information, see EXPADD.
   Volume(issue)/page/year: 9,59,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 9-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   EXPTAX Experimentelle Pathologie (1967-1980).  (Jena, Ger. Dem. Rep.)
   V.1-18, 1967-80.  For publisher information, see EXPADD.
   Volume(issue)/page/year: 9,59,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 9-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - body wall
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   EXPTAX Experimentelle Pathologie (1967-1980).  (Jena, Ger. Dem. Rep.)
   V.1-18, 1967-80.  For publisher information, see EXPADD.
   Volume(issue)/page/year: 9,59,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 9-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   EXPTAX Experimentelle Pathologie (1967-1980).  (Jena, Ger. Dem. Rep.)
   V.1-18, 1967-80.  For publisher information, see EXPADD.
   Volume(issue)/page/year: 9,59,1974
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   JOGNAU Journal of Genetics.  (Belghoria, India)  V.1-63, 1910-77.
   Discontinued.  Volume(issue)/page/year: 59,273,1966
 
TYPE OF TEST            : Heritable translocation test
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   JOGNAU Journal of Genetics.  (Belghoria, India)  V.1-63, 1910-77.
   Discontinued.  Volume(issue)/page/year: 59,273,1966

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
   
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***