*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RC1250000
CHEMICAL NAME           : 20-Norcrotalanan-11,15-dione,
                          3,8-didehydro-14,19-dihydro-12,13-dihydroxy-,
                          (13-alpha,14- alpha)-
CAS REGISTRY NUMBER     : 23291-96-5
LAST UPDATED            : 199606
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C16-H21-N-O6
MOLECULAR WEIGHT        : 323.38
WISWESSER LINE NOTATION : T55-11- 1A P EN IOV NVO BU FUTJ K1 LQ L1 MQ M1
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Dehydromonocrotaline
   * Monocrotaline pyrrole
   * Monocrotaline pyrrole metabolite
   * Monocrotaline, 3,8-didehydro-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Liver - other changes
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   12,299,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPTLAS Journal of Pathology.  (John Wiley & Sons, Inc., 605 Third Ave., New
   York, NY 10158) V.97-    1969-  Volume(issue)/page/year: 100,169,1970
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 mg/kg/5W-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   JPTLAS Journal of Pathology.  (John Wiley & Sons, Inc., 605 Third Ave., New
   York, NY 10158) V.97-    1969-  Volume(issue)/page/year: 118,121,1976
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1504 mg/kg/47W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   17,61,1982
 
                            *** END OF RECORD ***