*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RA0800000
CHEMICAL NAME           : Nitrous acid, sec-butyl ester
CAS REGISTRY NUMBER     : 924-43-6
BEILSTEIN REFERENCE NO. : 1720638
REFERENCE               : 4-01-00-01573 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C4-H9-N-O2
MOLECULAR WEIGHT        : 103.14
WISWESSER LINE NOTATION : ONOY2&1
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * sec-Butyl nitrite
   * Nitrous acid, 1-methylpropyl ester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 423 mg/kg
TOXIC EFFECTS :
   Liver - other changes
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   RCSADO Research Communications in Substances Abuse.  (PJD Pub. Ltd., P.O.Box
   966, Westbury, NY 11590) V.1-    1980-  Volume(issue)/page/year: 3,233,1982
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1753 ppm/1H
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - cyanosis
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   1,448,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 496 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 26,75,1979
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 ppm/7H/60D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in bladder weight
   Endocrine - changes in spleen weight
   Related to Chronic Data - death
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 5,134,1985
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale.  (Casa
   Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy)  V.2- 1927- 
   Volume(issue)/page/year: 56,816,1980
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 846 umol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   14,115,1989

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***